Dr. David Holtzman

Neurologist · Alzheimer's Disease · St. Louis, Missouri
  • 646 Publications

Since 2003, Dr. David Holtzman has been the Andrew and Gretchen Jones Professor and head of the department of neurology at the Washington University School of Medicine in St. Louis, Missouri.

Concurrently, he is the Associate Director of the Alzheimer’s Disease Research Center and a member of the Hope Center for Neurological Disorders. Dr. Holtzman and his research lab focus on identifying what causes cell dysfunction in the central nervous system in relation to Alzheimer’s disease. For his work, he has received the Paul Beeson Physician Faculty Scholar award in aging research, and the Potamkin prize for research on Alzheimer’s disease.

Most recently, Dr. Holtzman was the senior author of a study led by the Washington University School of Medicine on a genetic variant, ApoE4. This has been found to exacerbate brain damage triggered by another protein, tau, which is closely related to causing Alzheimer’s.

“Once tau accumulates, the brain degenerates. What we found was that when ApoE4 is there, it amplifies the toxic function of tau, which means that if we can reduce ApoE4 levels we may be able to stop the disease process.”
-Dr. David Holtzman


Experience

Scientific Director

Hope Center for Neurological Disorders

University of washington school of medicine

Professor of Neurology

University of Washington School of Medicine

University of washington school of medicine

Chairman of Neurology

University of Washington School of Medicine

Associate Director

Alzheimer's Disease Research Center


Education

University of california san francisco school of medicine

Post-Doctoral Research

University of California, San Francisco School of Medicine · 1989 - 1994

University of california san francisco school of medicine

Residency in Neurology

University of California, San Francisco School of Medicine · 1985 - 1989

Medical Degree

Northwestern University · 1985

Bachelor of Science

Northwestern University · 1983


Publications

Dr. David Holtzman has been involved in 646 publications. View publications ›


Locations

Dr. David Holtzman is affiliated with Washington University School of Medicine: Holtzman Lab at 660 S. Euclid Ave, St Louis, Missouri.