Dr. David Holtzman
- 646 Publications
Since 2003, Dr. David Holtzman has been the Andrew and Gretchen Jones Professor and head of the department of neurology at the Washington University School of Medicine in St. Louis, Missouri.
Concurrently, he is the Associate Director of the Alzheimer’s Disease Research Center and a member of the Hope Center for Neurological Disorders. Dr. Holtzman and his research lab focus on identifying what causes cell dysfunction in the central nervous system in relation to Alzheimer’s disease. For his work, he has received the Paul Beeson Physician Faculty Scholar award in aging research, and the Potamkin prize for research on Alzheimer’s disease.
Most recently, Dr. Holtzman was the senior author of a study led by the Washington University School of Medicine on a genetic variant, ApoE4. This has been found to exacerbate brain damage triggered by another protein, tau, which is closely related to causing Alzheimer’s.
“Once tau accumulates, the brain degenerates. What we found was that when ApoE4 is there, it amplifies the toxic function of tau, which means that if we can reduce ApoE4 levels we may be able to stop the disease process.”
-Dr. David Holtzman